MS-Helios

Advances in high-resolution mass spectrometry facilitate the identification of hundreds of
metabolites, thousands of proteins and their post-translational modifications. This remarkable
progress poses a challenge to data analysis and visualization, requiring methods to reduce
dimensionality and represent the data in a compact way. To provide a more holistic view, we
recently introduced circular proteome maps (CPMs). However, the CPM construction requires
prior data transformation and extensive knowledge of the Perl-based tool, Circos.
We present MS-Helios, an easy to use command line tool with multiple built-in data processing
functions, allowing non-expert users to construct CPMs or in general terms circular plots with a
non-genomic basis. MS-Helios automatically generates data and configuration files to create
high quality and publishable circular plots with Circos.