PingPongPro

IMPORTANT NOTE: This project has been migrated to GitHub and is no longer maintained here. Please refer to:
https://github.com/suhrig/pingpongpro

Piwi-interacting RNAs (piRNAs) are a class of small non-coding RNAs, predominantly active in the germ line. There, they limit the detrimental effect of transposons on the genome. They do so by forming a complex with Piwi proteins. The complex binds and then cleaves mRNA molecules of active transposons. The resulting mRNA fragments induce the production of more piRNAs, thus reinforcing the anti-transposon response in a feed-forward loop called the "ping-pong cycle".
A key question in ping-pong cycle research is identification of piRNAs which are amplified through the cycle. PingPongPro is a command-line tool for detecting ping-pong cycle activity in piRNA-Seq data.

PingPongPro was developed at the Institute of Molecular Biology gGmbH in Mainz.